Clinical trials
Welcome to the Clinical Trials page of the Australian Amyloidosis Network website!
This page is designed to be understandable for both patients and clinicians alike.
Clinical trials are subdivided into major amyloidosis types: ATTR, AL and Other.
Please SCROLL DOWN for full details
Clinical trials are listed here once the first health service site in Australia has fully opened the trial for patient screening and enrollment.
Once a trial has been posted as being open at one site, all other sites selected to participate for that trial will also be listed, even thought they may not yet be fully open.
Each trial for each site will be listed as “activated” (or open to recruitment), or “pending” (about to open to recruitment).
Please note : Listing a clinical trial on this website does not necessarily equate as endorsement of the trial by the Australian Amyloidosis Network. Any patient interested in a trial should discuss the pros and cons of the studies with their treating practitioner.
Contacts for each of the clinical trials are listed for health care professionals.
For each trial, the study title, patient group, and short description of key inclusion and exclusion criteria are provided.
The trial status at each site will be indicated by a symbol.
The key is as follows:
Systemic AL Amyloidosis trials
Currently, there are no actively recruiting trials in AL amyloidosis, although several are in set-up.
Trials using novel anti-fibrillar antibodies for newly diagnosed advanced cardiac AL amyloidosis, will hopefully open in the first quarter of 2021.
A clinical trial using pomalidomide, isatuximab and dexamethasone for relapsed/refractory AL amyloidosis is planning to open in Australia in the last quarter of 2021.
There are many others in the planning stage, so please keep checking this website regularly for updates!
Transthyretin Amyloidosis (ATTR) trials
A NEW ATTR TRIAL HAS OPENED IN AUSTRALIA !
This is currently only open at Liverpool Hospital in Sydney
Sites in Melbourne, Brisbane and Perth will hopefully open by March 2021.
In the meantime, patients can discuss their suitability for diflunisal, doxycycline and/or EGCG (green tea extract) treatment for their ATTR amyloidosis.
NEW ATTR TRIAL
Study Title: “CARDIO-TTRansform“
A Study to Evaluate the Efficacy and Safety of AKCEA-TTR-LRx in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
Clinical Trials Database Link https://clinicaltrials.gov/ct2/show/NCT04136171
PLEASE CONTINUE TO CHECK THIS SITE FOR REGULAR UPDATES!
Sites
New South Wales
| Status: | |
| Site: | Liverpool Hospital, Sydney |
| Contact: | Dr Gayathri Kumarasinghe |
Victoria
| Status: | |
| Site: | Box Hill Hospital, Melbourne |
| Email: | simon.gibbs@monash.edu |
| Phone: | 03 9094 9505 |
Queensland
| Status: | |
| Site: | Princess Alexandra Hospital, Brisbane |
| Email: | CindyHall@health.qld.gov.au |
| Phone: | 07 3176 5145 |
Patient Group:
Brief Description:
Key inclusion criteria:
Key exclusion criteria:
Access Clinical Trials Database
Sites
New South Wales
| Status: | |
| Site: | St Vincent’s Hospital, Sydney |
| Email: | Clare.coates@svha.org.au |
| Phone: | 02 8382 3073 |
| Status: | |
| Site: | Westmead Hospital, Sydney |
| Email: | mtay2576@uni.sydney.edu.au |
Queensland
| Status: | |
| Site: | Princess Alexandra Hospital, Brisbane |
| Email: | CindyHall@health.qld.gov.au |
| Phone: | 07 3176 5145 |
Victoria
| Status: | |
| Site: | Box Hill Hospital, Melbourne |
| Email: | simon.gibbs@monash.edu |
| Phone: | 03 9094 9505 |
Western Australia
| Status: | |
| Site: | Fiona Stanley Hospital |
| Email: | fsh.ahfcts@health.wa.gov.au |
Tasmania
| Status: | |
| Site: | The Royal Hobart Hospital |
| Contacts: | david.russell@ths.tas.gov.au |
Patient Group: Inherited ATTR (ATTRv) with neuropathy
Brief Description:
Key inclusion criteria: A diagnosis of inherited ATTR and reaching a certain level of neurologic impairment using the Neurologic Impairment Score (NIS)
Key exclusion criteria: Prior liver transplant or NYHA heart failure classification >2
Practical Point:
Access Clinical Trials Database
Sites
Western Australia
| Status: | |
| Site: | |
| Email: | Prof Merillee Needham |
Queensland
| Status: | |
| Site: | |
| Email: |
Victoria
| Status: | |
| Site: | Box Hill Hospital, Melbourne |
| Email: | suzi.jakicic@monash.edu |
| Phone: | 03 9094 9505 |