Clinical Trials2020-11-19T19:20:24+00:00

Clinical trials

Welcome to the Clinical Trials page of the Australian Amyloidosis Network website!

This page is designed to be understandable for both patients and clinicians alike.

Clinical trials are subdivided into major amyloidosis types: ATTR, AL and Other.

Please SCROLL DOWN for full details

Clinical trials are listed here once the first health service site in Australia has fully opened the trial for patient screening and enrollment.

Once a trial has been posted as being open at one site, all other sites selected to participate for that trial will also be listed, even thought they may not yet be fully open.

Each trial for each site will be listed as “activated” (or open to recruitment), or “pending” (about to open to recruitment).

Please note : Listing a clinical trial on this website does not necessarily equate as endorsement of the trial by the Australian Amyloidosis Network. Any patient interested in a trial should discuss the pros and cons of the studies with their treating practitioner.

Contacts for each of the clinical trials are listed for health care professionals.

For each trial, the study title, patient group, and short description of key inclusion and exclusion criteria are provided.

The trial status at each site will be indicated by a symbol.
The key is as follows:

Clinical trial key

Systemic AL Amyloidosis trials

Currently, there are no actively recruiting trials in AL amyloidosis, although several are in set-up.

Trials using novel anti-fibrillar antibodies for newly diagnosed advanced cardiac AL amyloidosis, will hopefully open in the first quarter of 2021.

A clinical trial using pomalidomide, isatuximab and dexamethasone for relapsed/refractory AL amyloidosis is planning to open in Australia in the last quarter of 2021.

There are many others in the planning stage, so please keep checking this website regularly for updates!

Transthyretin Amyloidosis (ATTR) trials

A NEW ATTR TRIAL HAS OPENED IN AUSTRALIA !

This is currently only open at Liverpool Hospital in Sydney

Sites in Melbourne, Brisbane and Perth will hopefully open by March 2021.

In the meantime, patients can discuss their suitability for diflunisal, doxycycline and/or EGCG (green tea extract) treatment for their ATTR amyloidosis.

NEW ATTR TRIAL

Study Title: “CARDIO-TTRansform

A Study to Evaluate the Efficacy and Safety of AKCEA-TTR-LRx in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Clinical Trials Database Link https://clinicaltrials.gov/ct2/show/NCT04136171

                                        PLEASE CONTINUE TO CHECK THIS SITE FOR REGULAR UPDATES!

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Sites

New South Wales

Status:
Site: Liverpool Hospital, Sydney
Contact: Dr Gayathri Kumarasinghe

Victoria

Status:
Site: Box Hill Hospital, Melbourne
Email: simon.gibbs@monash.edu
Phone: 03 9094 9505

Queensland

Status:
Site: Princess Alexandra Hospital, Brisbane
Email: CindyHall@health.qld.gov.au
Phone: 07 3176 5145

Patient Group

Brief Description:

Key inclusion criteria: 

Key exclusion criteria: 

Access Clinical Trials Database

Sites

New South Wales

Status:
Site: St Vincent’s Hospital, Sydney
Email: Clare.coates@svha.org.au
Phone: 02 8382 3073
Status:
Site: Westmead Hospital, Sydney
Email: mtay2576@uni.sydney.edu.au

Queensland

Status:
Site: Princess Alexandra Hospital, Brisbane
Email: CindyHall@health.qld.gov.au
Phone: 07 3176 5145

Victoria

Status:
Site: Box Hill Hospital, Melbourne
Email: simon.gibbs@monash.edu
Phone: 03 9094 9505

Western Australia

Status:
Site: Fiona Stanley Hospital
Email: fsh.ahfcts@health.wa.gov.au

Tasmania

Status:
Site: The Royal Hobart Hospital
Contacts: david.russell@ths.tas.gov.au

Patient Group: Inherited ATTR (ATTRv) with neuropathy

Brief Description:

Key inclusion criteria: A diagnosis of inherited ATTR and reaching a certain level of neurologic impairment using the Neurologic Impairment Score (NIS)

Key exclusion criteria: Prior liver transplant or NYHA heart failure classification >2

Practical Point: 

Access Clinical Trials Database

Sites

Western Australia

Status:
Site:
Email: Prof Merillee Needham

Queensland

Status:
Site:
Email:

Victoria

Status:
Site: Box Hill Hospital, Melbourne
Email: suzi.jakicic@monash.edu
Phone: 03 9094 9505