Symptoms may include
- pain, stiffness and fluid in the joints.
- numbness or tingling, sometimes associated with muscle weakness, in the fingers and hands. (Carpel Tunnel syndrome)
The following tests may be used:
- Urinalysis and blood tests to detect the amount of amyloid proteins in urine and blood.
- X-rays and CT scans to provide pictures of bone cysts and amyloid deposits in bones, joints, tendons, and ligaments.
- Tests to show if heart or lungs are affected.
There is no cure for dialysis-related amyloidosis but treatments may include:
- A successful kidney transplant in selected patient’s my stop the disease from progressing
- Newer, more effective hemodialysis filters
- Surgery may be needed to treat bone cysts, carpel tunnel and bone, joints and tendon problems
- Medication to control pain and inflammation.
Dialysis related amyloidosis has decreased with the use during dialysis of high-flux biocompatible membranes, which provide better clearance of beta2-m and are less likely to induce reactive inflammation.